# RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis

*PRI Rank #10 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 69 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07969-x |
| Corresponding authors | Mingjiang Xu, Chuan He |
| Institution | The University of Chicago, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1038/s41586-024-07969-x](https://doi.org/10.1038/s41586-024-07969-x)

## Topics

TET2 · RNA m5C oxidation · chromatin state regulation · myeloid malignancy · MBD6 · H2AK119ub · retrotransposon RNA · DNA 5-methylcytosine oxidation · haematopoietic stem cell self-renewal · open chromatin · methyl-CpG-binding-domain protein · H2AK119ub · TET2-mutant leukaemia · TET2 deficiency · Gene regulation · leukaemogenesis · haematopoiesis defects · Therapeutic target

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```