# Origins and impact of extrachromosomal DNA

*PRI Rank #9 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 134 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08107-3 |
| Corresponding authors | Paul S. Mischel, Mariam Jamal‐Hanjani, Charles Swanton |
| Institution | The Francis Crick Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41586-024-08107-3](https://doi.org/10.1038/s41586-024-08107-3)

## Topics

Extrachromosomal DNA · Extrachromosomal DNA · cancer · Gene amplification · Driver genes · immunomodulatory genes · inflammatory genes · lymphocyte-mediated immunity · immune effector processes · Immune cell infiltration · tissue-context-based selection · enhancers · promoters · lncRNA · ecDNA interactions in trans · Mutational processes · Tobacco exposure · homologous recombination deficiency · tumour stage · Targeted therapy · cytotoxic treatment · Metastasis · Overall survival · transcriptional landscape · Immunosuppression · tumour growth signals · 100,000 Genomes Project · Whole-genome sequencing · Gene amplification · ecDNA formation · ecDNA detection · Tumor heterogeneity · Genomic instability · Somatic mutations · Pan-cancer analysis · Tumor microenvironment · Gene amplification · structural variants · circular DNA · Cancer genomics

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```