# ctDNA-based molecular residual disease and survival in resectable colorectal cancer

*PRI Rank #7 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 144 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-03254-6 |
| Corresponding authors | Takayuki Yoshino, Eiji Oki |
| Institution | National Cancer Center Hospital East, Japan |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41591-024-03254-6](https://doi.org/10.1038/s41591-024-03254-6)

## Topics

Circulating tumor DNA · Minimal residual disease · Colorectal cancer · resectable colorectal cancer · CIRCULATE-Japan GALAXY study · Observational study · adjuvant chemotherapy (ACT) · disease-free survival · Overall survival · Cancer recurrence · ctDNA positivity · ctDNA clearance · ctDNA clearance · ctDNA clearance · ctDNA clearance · post-resection monitoring · stage II colon cancer · stage III colon cancer · stage IV colorectal cancer · MRD window · prognostic biomarker · actionable biomarker subsets · hazard ratio · Risk stratification · adjuvant therapy guidance · Liquid biopsy · Tumor recurrence · mortality risk · ctDNA monitoring · MRD detection

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```