# Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

*PRI Rank #6 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 170 |
| Journal | Annals of Oncology |
| Year | 2024 |
| DOI | 10.1016/j.annonc.2024.05.537 |
| Corresponding authors | T. Powles |
| Institution | Queen Mary University of London, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1016/j.annonc.2024.05.537](https://doi.org/10.1016/j.annonc.2024.05.537)

## Topics

Renal cell carcinoma · Renal cell carcinoma · ESMO Clinical Practice Guideline · diagnosis · treatment · follow-up · incidence · malignancy · clear cell renal cell carcinoma · non-clear cell renal cell carcinoma · papillary renal cell carcinoma · chromophobe renal cell carcinoma · sarcomatoid differentiation · VHL gene · mTOR pathway · VEGF pathway · tyrosine kinase inhibitors · Immune checkpoint inhibition · PD-1 · PD-L1 · CTLA-4 · sunitinib · pazopanib · nivolumab · ipilimumab · pembrolizumab · axitinib · cabozantinib · lenvatinib · everolimus · temsirolimus · bevacizumab · combination immunotherapy · nephrectomy · cytoreductive nephrectomy · partial nephrectomy · metastasectomy · ablative therapies · stereotactic body radiotherapy · Targeted therapy · first-line treatment · second-line therapy · prognostic risk groups · IMDC risk score · MSKCC risk score · Biomarker · staging · TNM classification · metastatic renal cell carcinoma · localized renal cell carcinoma · Adjuvant therapy · surveillance · hereditary renal cell carcinoma · von Hippel-Lindau disease · angiogenesis · Tumor microenvironment · clinical trial · Overall survival · progression-free survival · Objective response rate

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```