# Precision treatment in advanced hepatocellular carcinoma

*PRI Rank #5 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 197 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.01.007 |
| Corresponding authors | Jia Fan, Cun Wang, Qiang Gao |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1016/j.ccell.2024.01.007](https://doi.org/10.1016/j.ccell.2024.01.007)

## Topics

Liver cancer · advanced hepatocellular carcinoma · Precision cancer care · Precision medicine · Targeted therapy · Biomarker · Molecular target · sorafenib · lenvatinib · regorafenib · cabozantinib · ramucirumab · Immune checkpoint inhibition · atezolizumab · bevacizumab · nivolumab · pembrolizumab · tremelimumab · durvalumab · VEGF pathway · PD-1/PD-L1 pathway · CTLA-4 · Tumor microenvironment · Genomic profiling · next-generation sequencing · Tumor mutational burden · microsatellite instability · TERT promoter mutations · TP53 mutations · CTNNB1 mutation · ARID1A · MET amplification · FGF19 amplification · FGFR inhibition · HER2 amplification · RAS/MAPK pathway · Wnt/β-catenin pathway · PI3K/AKT/mTOR pathway · alpha-fetoprotein · Barcelona Clinic Liver Cancer staging · Cirrhosis · hepatitis B virus · hepatitis C virus · systemic therapy · combination immunotherapy · Biomarker-driven clinical trial · patient selection · Acquired drug resistance · transcriptomic subtypes · multi-kinase inhibitors · angiogenesis inhibition

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```