# A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening

*PRI Rank #4 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 214 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2304714 |
| Corresponding authors | William M Grady |
| Institution | Massachusetts General Hospital and Harvard Medical School, Canada |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1056/nejmoa2304714](https://doi.org/10.1056/nejmoa2304714)

## Topics

Colorectal cancer · Circulating tumor DNA · Blood-based biomarkers · Colorectal cancer screening · early detection · Colorectal cancer screening · Advanced neoplasia · Advanced neoplasia · sensitivity · specificity · clinical validity · average-risk screening population · stage I colorectal cancer · stage II colorectal cancer · stage III colorectal cancer · nonadvanced precancerous lesions · screening adherence · colorectal cancer-related mortality · Liquid biopsy · ECLIPSE trial · Guardant Health · Cancer biomarker · DNA methylation · noninvasive cancer screening · coprimary outcomes · positive predictive value · negative predictive value

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```