# Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

*PRI Rank #19 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 94 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adf2341 |
| Corresponding authors | Shervin Tabrizi, J. Christopher Love, Sangeeta N. Bhatia, Viktor A. Adalsteinsson |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1126/science.adf2341](https://doi.org/10.1126/science.adf2341)

## Topics

Liquid biopsy · cell-free DNA · Circulating tumor DNA · cfDNA clearance · priming agents · early cancer detection · Disease monitoring · sensitivity enhancement · nanoparticles · DNA-binding antibodies · intravenous administration · cfDNA recovery · tumor-bearing mice · small tumor detection · in vivo augmentation · blood draw · Sequencing · analyte scarcity · cfDNA-clearing cells · Circulating tumor DNA

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```