# Single-cell and spatial transcriptomics analysis of non-small cell lung cancer

*PRI Rank #17 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 102 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-48700-8 |
| Corresponding authors | Ana Cvejic |
| Institution | Wellcome Sanger Institute, Denmark |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41467-024-48700-8](https://doi.org/10.1038/s41467-024-48700-8)

## Topics

Non-small cell lung cancer · adenocarcinoma · squamous-cell carcinoma · Lung cancer · Single-cell RNA sequencing · Spatial transcriptomics · Tumor microenvironment · tumour ecosystem · myeloid cells · Tumor-associated macrophages · M2 macrophage polarization · NK cells · T cells · NK cell cytotoxicity · Immune checkpoint inhibition · macrophage reprogramming · cholesterol export · foetal-like transcriptional signature · iron efflux · immune cell composition · co-expression analysis · treatment-naive patients · Multi-omics analysis · cell type composition · transcriptional reprogramming · cancer-related mortality · immune evasion · tumour-promoting inflammation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```