# Prognostic genome and transcriptome signatures in colorectal cancers

*PRI Rank #16 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 103 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07769-3 |
| Corresponding authors | Kui Wu, Bengt Glimelius, Cong Lin, Tobias Sjöblom |
| Institution | Uppsala University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41586-024-07769-3](https://doi.org/10.1038/s41586-024-07769-3)

## Topics

Colorectal cancer · Somatic mutations · Whole-genome sequencing · Transcriptomics · Driver genes · Population-based study · long-term follow-up · pathway co-mutations · mutation timing analysis · Mutational processes · Mutational signatures · Wnt/β-catenin pathway · EGFR pathway · TGFβ pathway · CYB gene · mitochondrial gene mutations · regulatory elements · Copy number variation · COSMIC SBS44 signature · survival analysis · gene expression classification · prognostic subtypes · microsatellite instability · hypoxia · Immune cell infiltration · stromal cell infiltration · Integrative genomic analysis · Prognosis · Personalized cancer therapy · primary colorectal tumors · cancer-causing mutations · Genomic alterations · Clinical outcome · expression subtypes · Tumor microenvironment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```