# The genomic landscape of 2,023 colorectal cancers

*PRI Rank #11 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 118 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07747-9 |
| Corresponding authors | Ian Tomlinson |
| Institution | Institute of Cancer Research, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41586-024-07747-9](https://doi.org/10.1038/s41586-024-07747-9)

## Topics

Colorectal cancer · Colorectal cancer · Whole-genome sequencing · Mutational landscape · Driver genes · microsatellite-stable CRC · microsatellite instability · chromosomal instability · 100,000 Genomes Project · molecular subgroups · prognostic associations · Mutational landscape · Escherichia coli pks+ · colibactin · rectal cancers · SBS93 mutational signature · diet as risk factor · Smoking · immune-escape driver mutations · Hypermutation · HLA copy number changes · BRCA1 · IDH1 · actionable mutations · Non-coding genome mutations · molecular pathways in CRC · Genomic landscape · Copy number variation · Mutational signatures · colorectum anatomical spectrum · rare molecular subgroups · patient care optimization · Driver genes · Somatic mutations · tumor genomics · Cancer genomics · APC · KRAS · TP53 · mismatch repair deficiency · Hypermutation · immune evasion · structural variants · indel signatures · cancer aetiology · Integrative genomic analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```