# Tumour evolution and microenvironment interactions in 2D and 3D space

*PRI Rank #10 · Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 129 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08087-4 |
| Corresponding authors | William E. Gillanders, Ryan C. Fields, Benjamin J. Raphael, Feng Chen, Li Ding |
| Institution | Washington University in St. Louis, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026)

**Paper link:** [10.1038/s41586-024-08087-4](https://doi.org/10.1038/s41586-024-08087-4)

## Topics

Tumor evolution · Tumor microenvironment · Spatial transcriptomics · Visium spatial transcriptomics · Single-nucleus RNA sequencing · CODEX (co-detection by indexing) · tumour microregions · spatial subclones · Intratumour heterogeneity · Copy number variation · Somatic mutations · oncogenic activity · metabolic activity · antigen presentation · Immune cell infiltration · macrophages · tumour boundaries · immune hot neighbourhoods · immune cold neighbourhoods · immune exhaustion · 3D tumour reconstruction · serial section co-registration · stromal components · cancer cell clusters · Subclonal expansion · spatial tumour heterogeneity · unsupervised deep-learning algorithm · multimodal data integration · Metastasis · tumour spatial organization · leading edge biology · tumour habitats · Clonal evolution

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```