# Human organoids with an autologous tissue-resident immune compartment

*PRI Rank #8 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 90 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07791-5 |
| Corresponding authors | Lauriane Cabon, J. Gray Camp, Nikolche Gjorevski |
| Institution | Roche Innovation Center Basel, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1038/s41586-024-07791-5](https://doi.org/10.1038/s41586-024-07791-5)

## Topics

human intestinal immuno-organoids · tissue-resident memory T cells · TRM cells · epithelial-immune interactions · intraepithelial T cells · Single-cell RNA sequencing · cancer-targeting biologics · immunotherapy-associated intestinal inflammation · CD8+ T cell activation · CD8+ T cells · T helper-1-like CD4+ population · Rho pathway · autologous immune compartment · epithelial barrier surveillance · cell motility and adhesion programs · Tumor organoid generation · effector T cell differentiation · interlineage immune interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```