# CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases

*PRI Rank #7 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 104 |
| Journal | Gut |
| Year | 2024 |
| DOI | 10.1136/gutjnl-2024-333617 |
| Corresponding authors | Zexian Liu, Rui-Hua Xu, Hui Luo |
| Institution | Sun Yat-sen University Cancer Center, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1136/gutjnl-2024-333617](https://doi.org/10.1136/gutjnl-2024-333617)

## Topics

Peritoneal metastasis · Immune checkpoint blockade · sintilimab · Single-cell RNA sequencing · Tumor microenvironment · SPP1+ macrophages · Matrix CAFs · Tumor stroma · complement C3 · C3a receptor 1 · C3-C3AR1 axis · Tumor-associated macrophages · Tumor-stroma interactions · Therapy resistance · Immunosuppressive tumor microenvironment · Peritoneal metastasis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```