# Progressive plasticity during colorectal cancer metastasis

*PRI Rank #5 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 123 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08150-0 |
| Corresponding authors | Dana Pe’er, Karuna Ganesh |
| Institution | Memorial Sloan Kettering Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1038/s41586-024-08150-0](https://doi.org/10.1038/s41586-024-08150-0)

## Topics

colorectal cancer metastasis · phenotypic plasticity · LGR5+ intestinal stem-like states · fetal progenitor state · non-canonical differentiation · squamous-like states · neuroendocrine-like states · Patient-derived organoids · multilineage differentiation potential · microenvironment cues · PROX1 · repression of non-intestinal lineages · Cellular plasticity · Therapy resistance · biospecimen trios · Cellular plasticity · lineage reprogramming

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```