# Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

*PRI Rank #3 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 154 |
| Journal | Nature Cancer |
| Year | 2024 |
| DOI | 10.1038/s43018-024-00775-4 |
| Corresponding authors | Valerie M. Weaver |
| Institution | University of California San Francisco, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1038/s43018-024-00775-4](https://doi.org/10.1038/s43018-024-00775-4)

## Topics

Tumor-associated macrophages · CD8+ T cells · Extracellular matrix remodeling · metabolic reprogramming · breast cancer microenvironment · T cell dysfunction · Extracellular matrix remodeling · Immunosuppressive tumor microenvironment · macrophage-T cell interaction · Tumor stroma · metabolic competition · Immune evasion · collagen-mediated immune exclusion

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```