# PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay

*PRI Rank #20 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 62 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.02.002 |
| Corresponding authors | Changhao Chen, Tianxin Lin |
| Institution | Sun Yat-sen University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1016/j.ccell.2024.02.002](https://doi.org/10.1016/j.ccell.2024.02.002)

## Topics

PDGFRα+ITGA11+ fibroblasts · Cancer-associated fibroblasts · lymphovascular invasion · Lymphatic metastasis · early-stage bladder cancer · Single-cell RNA sequencing · Spatial transcriptomics · ITGA11-SELE interaction · lymphangiogenesis · Endothelial cells · SRC-p-VEGFR3-MAPK pathway · CHI3L1 · Intravasation · Lymphatic metastasis · CAF heterogeneity · PDGFRα+ITGA11+ CAF-deficient mouse model · SELE surface receptor · extracellular matrix alignment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```