# Deterministic reprogramming of neutrophils within tumors

*PRI Rank #2 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 187 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adf6493 |
| Corresponding authors | Melissa Ng, Immanuel Kwok, Leonard Tan, Chuyan Shi, Lai Guan Ng |
| Institution | Singapore Immunology Network (SIgN), Singapore |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1126/science.adf6493](https://doi.org/10.1126/science.adf6493)

## Topics

neutrophil reprogramming · dcTRAIL-R1+ neutrophils · epigenetic modifications · transcriptional reprogramming · proteomic modifications · immature neutrophils · mature neutrophils · terminal differentiation · glycolytic niche · hypoxic niche · tumor core localization · Angiogenesis · neutrophil trajectory · neutrophil ontogeny · Cancer immunotherapy · Cancer immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```