# Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

*PRI Rank #18 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 65 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07330-2 |
| Corresponding authors | L. Francisco Lorenzo‐Martín, Matthias P. Lütolf |
| Institution | École Polytechnique Fédérale de Lausanne (EPFL), Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1038/s41586-024-07330-2](https://doi.org/10.1038/s41586-024-07330-2)

## Topics

Tumor organoids · Tumor organoids · Tumor progression · tumorigenesis ex vivo · microfabrication · optogenetic control · tissue engineering · blue-light exposure · oncogenic activation · single-cell resolution · real-time tracking · Tumor heterogeneity · Inter-patient heterogeneity · Colorectal cancer · topobiological complexity · oncogenic transformation · spatiotemporal control · cell-intrinsic determinants · cell-extrinsic parameters · Tumor progression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```