# Sonodynamic Nano-LYTACs Reverse Tumor Immunosuppressive Microenvironment for Cancer Immunotherapy

*PRI Rank #17 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 67 |
| Journal | Journal of the American Chemical Society |
| Year | 2024 |
| DOI | 10.1021/jacs.4c13022 |
| Corresponding authors | Kanyi Pu |
| Institution | Nanyang Technological University, Singapore |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1021/jacs.4c13022](https://doi.org/10.1021/jacs.4c13022)

## Topics

Lysosome targeting chimera · Lysosome targeting chimera · sonodynamic therapy · Tumor-associated macrophages · IL-4R degradation · interleukin 4 receptor · CD206 · interleukin 10 · Immunosuppressive tumor microenvironment · regulatory T cells · dendritic cell maturation · T effector cells · membrane protein degradation · Tumor-associated macrophages · tumor retention · Lung metastasis · Cancer immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```