# Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer

*PRI Rank #15 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 68 |
| Journal | Biomedicine & Pharmacotherapy |
| Year | 2024 |
| DOI | 10.1016/j.biopha.2024.117550 |
| Corresponding authors | Dianwen Ju, Ziyu Wang, Xuyao Zhang |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1016/j.biopha.2024.117550](https://doi.org/10.1016/j.biopha.2024.117550)

## Topics

TROP2 · antibody-drug conjugate · Pancreatic cancer · αTROP2-MMAE · MMAE · autophagy · caspase-9/PARP pathway · Apoptosis · autophagosomes · autophagic flux · PI3K/Akt/mTOR pathway · autophagy inhibitors · cytoprotective autophagy · BxPC3 cells · subcutaneous xenograft model · RNA sequencing · combination therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```