# An atlas of epithelial cell states and plasticity in lung adenocarcinoma

*PRI Rank #13 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 76 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07113-9 |
| Corresponding authors | Jichao Chen, Linghua Wang, Humam Kadara |
| Institution | The University of Texas MD Anderson Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1038/s41586-024-07113-9](https://doi.org/10.1038/s41586-024-07113-9)

## Topics

Lung cancer · Single-cell RNA sequencing · Cell states · Cellular plasticity · KRAS mutations · KRT8+ alveolar intermediate cells · Epithelial cells · oncogenic driver mutations · tumor precursor cells · tobacco carcinogen exposure · Epithelial differentiation · aneuploidy · lineage tracing · Tumor organoids · KRAS inhibition · AT2-to-tumor transformation · lung precancer · KRT8 expression · Lung cancer

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```