# THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

*PRI Rank #12 · Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 79 |
| Journal | Molecular Cancer |
| Year | 2024 |
| DOI | 10.1186/s12943-024-02180-y |
| Corresponding authors | Xinwei Han, Jinhai Deng, Zaoqu Liu |
| Institution | The First Affiliated Hospital of Zhengzhou University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026)

**Paper link:** [10.1186/s12943-024-02180-y](https://doi.org/10.1186/s12943-024-02180-y)

## Topics

Matrix CAFs · COL8A1 · Therapy resistance · Epithelial-mesenchymal transition · PI3K/Akt/mTOR pathway · Colorectal cancer · ITGB1 receptor · Single-cell RNA sequencing · Spatial transcriptomics · Extracellular matrix remodeling · CAF heterogeneity · THBS2 · AKT inhibitor · ITGB1 knockdown · Therapy resistance · Tumor-stroma interactions · Tumor-stroma interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```