# Rapid species-level metagenome profiling and containment estimation with sylph

*PRI Rank #9 · Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 74 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-024-02412-y |
| Corresponding authors | Jim Shaw, Yun William Yu |
| Institution | University of Toronto, Canada |

**Ranking page:** [Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026)

**Paper link:** [10.1038/s41587-024-02412-y](https://doi.org/10.1038/s41587-024-02412-y)

## Topics

sylph · Metagenomics · genome-to-metagenome containment · average nucleotide identity (ANI) · zero-inflated Poisson k-mer statistics · species-level detection · CAMI2 Marine dataset · Kraken2 · multisample profiling · ANI-based metagenome-wide association study · Parkinson disease · butyrate-PD associations · strain-level analysis · Bacterial genomes · Phage genomes · Gut microbiome · RefSeq · low-coverage genomes · containment ANI estimation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```