# Bacterial defense systems exhibit synergistic anti-phage activity

*PRI Rank #19 · Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 61 |
| Journal | Cell Host & Microbe |
| Year | 2024 |
| DOI | 10.1016/j.chom.2024.01.015 |
| Corresponding authors | Franklin L. Nóbrega |
| Institution | University of Southampton, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026)

**Paper link:** [10.1016/j.chom.2024.01.015](https://doi.org/10.1016/j.chom.2024.01.015)

## Topics

Anti-phage defense systems · Anti-phage activity · synergistic defense mechanisms · Zorya II · Druantia III · ietAS · tmn · Gabija complex · Septu I · PrrC · ATPase domain · non-random co-occurrence · negative association · Escherichia coli · phage predation · immune repertoires · host-specific phages · negative epistasis · defense system compatibility

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacteriophages and microbial interactions Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacteriophages-and-microbial-interactions/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```