# Architecture and activation mechanism of the bacterial PARIS defence system

*PRI Rank #8 · Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 43 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07772-8 |
| Corresponding authors | Amar Deep, Kevin D. Corbett |
| Institution | University of California, San Diego, United States |

**Ranking page:** [Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026)

**Paper link:** [10.1038/s41586-024-07772-8](https://doi.org/10.1038/s41586-024-07772-8)

## Topics

PARIS defence system · bacterial defence system · architecture · activation mechanism

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```