# Bacterial defense systems exhibit synergistic anti-phage activity

*PRI Rank #3 · Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 61 |
| Journal | Cell Host & Microbe |
| Year | 2024 |
| DOI | 10.1016/j.chom.2024.01.015 |
| Corresponding authors | Franklin L. Nóbrega |
| Institution | University of Southampton, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026)

**Paper link:** [10.1016/j.chom.2024.01.015](https://doi.org/10.1016/j.chom.2024.01.015)

## Topics

Bacterial anti-phage defense systems · anti-phage activity · Defense system interactions · negative association analysis · Zorya II · Druantia III · ietAS defense system · tmn defense system · Gabija · Septu I · PrrC · sensory switch ATPase domain · Escherichia coli strains · Defense system interactions · negative epistasis · bacterial genome analysis · Bacterial anti-phage defense systems · Bacterial innate immunity · Bacterial anti-phage defense systems · Defense system interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```