# Diverse anti-defence systems are encoded in the leading region of plasmids

*PRI Rank #2 · Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 63 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07994-w |
| Corresponding authors | David Burstein |
| Institution | Tel-Aviv University, Israel |

**Ranking page:** [Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026)

**Paper link:** [10.1038/s41586-024-07994-w](https://doi.org/10.1038/s41586-024-07994-w)

## Topics

Plasmid leading region · anti-defence systems · anti-CRISPR proteins · Anti-restriction systems · anti-SOS proteins · CRISPR-Cas systems · Restriction-modification systems · SOS-response genes · conjugation · Horizontal gene transfer · Antibiotic resistance dissemination · Single-stranded DNA promoters · Mobile genetic elements · plasmid dissemination · gene mobilization · Phage counter-defence · Bacterial conjugation · bacterial immunity evasion · Plasmid establishment · gene localization on plasmids

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```