# PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa

*PRI Rank #15 · Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 34 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-53638-y |
| Corresponding authors | Shuaiqi Guo, Lori L. Burrows, Jun Liu |
| Institution | Yale School of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026)

**Paper link:** [10.1038/s41467-024-53638-y](https://doi.org/10.1038/s41467-024-53638-y)

## Topics

Type IV pili · Pseudomonas aeruginosa · PilY1 · cryo-electron tomography · subtomogram averaging · integrative modelling · PilQ secretin · PilQ secretin · minor pilin complex · pilus extension · pilus retraction · 7-fold symmetric cage-like structures · champagne-cork-shaped structure · periplasm · Outer membrane · PilY1-minor-pilin priming complex · gate-keeping mechanism · biofilm formation · surface motility

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```