# Structure and mechanism of the Zorya anti-phage defence system

*PRI Rank #12 · Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 36 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08493-8 |
| Corresponding authors | Haidai Hu, Marc Erhardt, Simon A. Jackson, Nicholas M. I. Taylor |
| Institution | University of Copenhagen, Denmark |

**Ranking page:** [Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026](https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026)

**Paper link:** [10.1038/s41586-024-08493-8](https://doi.org/10.1038/s41586-024-08493-8)

## Topics

Zorya anti-phage defence system · Bacterial anti-phage defense systems · ZorA-ZorB membrane complex · ZorC · ZorD · Bacterial anti-phage defense systems · Cryo-EM structure · flagellar motor stator homology · MotAB-like proton channel · membrane potential-dependent defence · proton motive force · Abortive infection · Bacterial anti-phage defense systems · nuclease domain · helicase domain · Membrane depolarization · ZorAB rotary motor mechanism · Bacterial innate immunity · defence island · Phage-bacteria arms race

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```