# Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

*PRI Rank #6 · Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 149 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2408308 |
| Corresponding authors | Oussama M Wazni |
| Institution | Cleveland Clinic, United States |

**Ranking page:** [Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026](https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026)

**Paper link:** [10.1056/nejmoa2408308](https://doi.org/10.1056/nejmoa2408308)

## Topics

Left atrial appendage occlusion · Oral anticoagulation · Catheter ablation · CHA2DS2-VASc score · Stroke risk assessment · Thromboembolic events · Major bleeding · clinically relevant nonmajor bleeding · Noninferiority trial · Superiority testing · Procedural complications · Left atrial appendage occlusion · OPTION trial · OPTION trial · Boston Scientific · Composite end point of death, stroke, or embolism · Randomized 1:1 assignment · Left atrial appendage occlusion

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026. https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```