# Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

*PRI Rank #3 · Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 279 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-03114-3 |
| Corresponding authors | Emmanuel Ekanem |
| Institution | Icahn School of Medicine at Mount Sinai, United States |

**Ranking page:** [Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026](https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026)

**Paper link:** [10.1038/s41591-024-03114-3](https://doi.org/10.1038/s41591-024-03114-3)

## Topics

Pulsed field ablation · atrial fibrillation · Pentaspline ablation catheter · MANIFEST-17K study · Post-approval registry study · Esophageal injury · Pulmonary vein stenosis · Phrenic nerve injury · Cardiac tamponade · Vascular access complication · Stroke · Procedural mortality · Coronary artery spasm · Hemolysis-related acute renal failure · Hemodialysis · Thermal ablation collateral damage · paroxysmal atrial fibrillation · Persistent atrial fibrillation · Myocardial tissue selectivity · Pulsed field ablation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026. https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```