# The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

*PRI Rank #9 · Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 28 |
| Journal | Microbiome |
| Year | 2024 |
| DOI | 10.1186/s40168-024-01958-y |
| Corresponding authors | Chao Ran, Zhigang Zhou |
| Institution | Chinese Academy of Agricultural Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026](https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026)

**Paper link:** [10.1186/s40168-024-01958-y](https://doi.org/10.1186/s40168-024-01958-y)

## Topics

Gut microbiota · Cetobacterium somerae · Spring viremia of carp virus · Spring viremia of carp virus · TLR2 · type I interferon · TLR2-Myd88 signaling · neutrophil response · germ-free zebrafish · 16S rRNA gene sequencing · gnotobiotic zebrafish · C. somerae exopolysaccharides · C. somerae exopolysaccharides · rhabdoviral infection · antiviral innate immunity · oral antibiotics treatment · CsEPS-TLR2-type I IFN signaling axis · commensal bacteria · microbiome-mediated antiviral effect

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026. https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```