# Tissue Accumulation and Biotransformation of 6PPD-Quinone in Adult Zebrafish and Its Effects on the Intestinal Microbial Community

*PRI Rank #3 · Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 36 |
| Journal | Environmental Science & Technology |
| Year | 2024 |
| DOI | 10.1021/acs.est.4c01409 |
| Corresponding authors | Zhifeng Chen, Zongwei Cai |
| Institution | Guangdong University of Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026](https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026)

**Paper link:** [10.1021/acs.est.4c01409](https://doi.org/10.1021/acs.est.4c01409)

## Topics

6PPD-quinone · 6PPD-quinone · species-specific toxicity · Danio rerio · coho salmon · toxicokinetics · tissue accumulation · biotransformation · hydroxylation · O-sulfonation · phase I enzymes · phase II enzymes · enzyme binding affinity · Gut microbiota · Nocardioides · Rhodococcus · Whole-genome sequencing · xenobiotic metabolism · detoxification pathways · in silico binding analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Aquaculture disease management and microbiota Papers, Class of 2026. https://pri.pepkio.com/top-papers/aquaculture-disease-management-and-microbiota/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```