# LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S. aureus biofilms

*PRI Rank #9 · Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 22 |
| Journal | Microbial Cell Factories |
| Year | 2024 |
| DOI | 10.1186/s12934-024-02359-4 |
| Corresponding authors | Shuguang Lu, Xiancai Rao |
| Institution | Army Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026](https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026)

**Paper link:** [10.1186/s12934-024-02359-4](https://doi.org/10.1186/s12934-024-02359-4)

## Topics

LysSYL · phage endolysin · Staphylococcus aureus · biofilm eradication · methicillin-resistant S. aureus (MRSA) · phage SYL · Kayvirus genus · MRSA XN108 · MRSA USA300 · mixed-species biofilms · bacterial persisters · vancomycin combination therapy · peritonitis mouse model · broad-spectrum antimicrobial activity · staphylococcal infections · phage therapy · bacterial cell lysis · in vivo bacterial load reduction

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026. https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```