# Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria

*PRI Rank #12 · Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 22 |
| Journal | Journal of the American Chemical Society |
| Year | 2024 |
| DOI | 10.1021/jacs.4c06520 |
| Corresponding authors | Lynette Cegelski, Paul A. Wender |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026](https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026)

**Paper link:** [10.1021/jacs.4c06520](https://doi.org/10.1021/jacs.4c06520)

## Topics

biguanide-vancomycin conjugates · V–C6–Bg-PhCl (5e) · ESKAPE pathogens · vancomycin-resistant enterococcus · mycobacteria · Gram-negative bacteria · Gram-positive bacteria · biofilm-associated bacteria · cell wall synthesis inhibition · vancomycin binding sites · biguanide association with cell-surface anions · oritavancin · antibiotic-resistant infections · antibiotic-tolerant bacteria · biguanidinylation · vancomycin · broad-spectrum antibiotics · chronic infections

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Antimicrobial Resistance in Staphylococcus Papers, Class of 2026. https://pri.pepkio.com/top-papers/antimicrobial-resistance-in-staphylococcus/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```