# Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin

*PRI Rank #19 · Topics and Trends in Most Cited Antibiotic Resistance in Bacteria Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/antibiotic-resistance-in-bacteria/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 57 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08095-4 |
| Corresponding authors | Benjamin P. Howden, Glen P. Carter |
| Institution | The University of Melbourne, Australia |

**Ranking page:** [Topics and Trends in Most Cited Antibiotic Resistance in Bacteria Papers, Class of 2026](https://pri.pepkio.com/top-papers/antibiotic-resistance-in-bacteria/2026)

**Paper link:** [10.1038/s41586-024-08095-4](https://doi.org/10.1038/s41586-024-08095-4)

## Topics

rifaximin · daptomycin · vancomycin-resistant Enterococcus faecium · VREfm · cross-resistance · RNA polymerase · prdRAB operon · cell membrane remodelling · hepatic encephalopathy prophylaxis · liver cirrhosis · multidrug-resistant pathogens · Last-resort antibiotics · antibiotic binding reduction · RNA polymerase mutations

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Antibiotic Resistance in Bacteria Papers, Class of 2026. https://pri.pepkio.com/top-papers/antibiotic-resistance-in-bacteria/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```