# Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

*PRI Rank #6 · Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 30 |
| Journal | Advanced Science |
| Year | 2024 |
| DOI | 10.1002/advs.202309482 |
| Corresponding authors | Jie Liu, Jingdun Xie |
| Institution | Sun Yat-Sen University Cancer Center, China |

**Ranking page:** [Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026)

**Paper link:** [10.1002/advs.202309482](https://doi.org/10.1002/advs.202309482)

## Topics

injectable hydrogel delivery system · heterogeneous hydrogel microspheres · ropivacaine · microfluidic chip fabrication · in situ alkalization · self-healing hydrogel matrix · carboxymethylcellulose modification (CMC-ADH) · oxidized hyaluronic acid (OHA) · dexmedetomidine co-delivery · core-shell microsphere structure · sustained local anesthetic delivery · high drug loading capacity · Peripheral nerve blocks · sensory blockade duration · motor blockade duration · sustained local anesthetic delivery · synergistic analgesia · Postoperative pain management · Opioid consumption reduction · sustained local anesthetic delivery

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```