# An Engineered Bionic Nanoparticle Sponge as a Cytokine Trap and Reactive Oxygen Species Scavenger to Relieve Disc Degeneration and Discogenic Pain

*PRI Rank #15 · Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 20 |
| Journal | ACS Nano |
| Year | 2024 |
| DOI | 10.1021/acsnano.3c08097 |
| Corresponding authors | Zengwu Shao, Xiangcheng Qing, Yizhong Peng |
| Institution | Huazhong University of Science and Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026)

**Paper link:** [10.1021/acsnano.3c08097](https://doi.org/10.1021/acsnano.3c08097)

## Topics

MnO2@TMNP nanomaterial · MnO2 nanoparticles · TrkA-overexpressing macrophage membrane coating · cytokine trap · reactive oxygen species scavenging · M1 macrophage polarization · nucleus pulposus cell apoptosis · Nerve growth factor binding · sensory nerve ingrowth · extracellular matrix degradation · Rat intervertebral disc degeneration model · discogenic pain · mechanical hyperalgesia · thermal hyperalgesia · calcitonin gene-related peptide (CGRP) · Substance P · dorsal root ganglion · Glial Fibrillary Acidic Protein (GFAP) · c-FOS signaling · Biomimetic nanoparticle

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Anesthesia and Pain Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/anesthesia-and-pain-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```