# The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom

*PRI Rank #9 · Topics and Trends in Most Cited Amphibian and Reptile Biology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/amphibian-and-reptile-biology/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 19 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2313440121 |
| Corresponding authors | Darin R. Rokyta |
| Institution | Florida State University, United States |

**Ranking page:** [Topics and Trends in Most Cited Amphibian and Reptile Biology Papers, Class of 2026](https://pri.pepkio.com/top-papers/amphibian-and-reptile-biology/2026)

**Paper link:** [10.1073/pnas.2313440121](https://doi.org/10.1073/pnas.2313440121)

## Topics

Crotalus adamanteus · Crotalus adamanteus · Venom variation · Venom variation · chromosome-level genome assembly · chromatin accessibility · histone modifications · cis-regulatory elements · trans-regulatory factors · Venom gene expression · epigenomic changes · promoters · enhancers · candidate transcription factors · growth signaling · Diel activity patterns · gene regulatory networks · ontogenetic diet shift · Venom gene expression · life-history trait evolution

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Amphibian and Reptile Biology Papers, Class of 2026. https://pri.pepkio.com/top-papers/amphibian-and-reptile-biology/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```