# Biomarker Changes during 20 Years Preceding Alzheimer’s Disease

*PRI Rank #6 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 224 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2310168 |
| Corresponding authors | Jianping Jia |
| Institution | Capital Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1056/nejmoa2310168](https://doi.org/10.1056/nejmoa2310168)

## Topics

China Cognition and Aging Study · nested case-control study · Sporadic Alzheimer's disease · Cerebrospinal fluid biomarkers · Aβ42 · p-tau181 · Total tau · neurofilament light · hippocampal volume · Biomarker temporal trajectory · Preclinical Alzheimer's disease · Cognitive decline · brain imaging · longitudinal cohort study · biomarker divergence timing · Biomarker temporal trajectory · cognitively unimpaired individuals · matched case-control design · NCT03653156

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```