# Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care

*PRI Rank #5 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 242 |
| Journal | JAMA |
| Year | 2024 |
| DOI | 10.1001/jama.2024.13855 |
| Corresponding authors | Sebastian Palmqvist |
| Institution | Lund University, Sweden |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1001/jama.2024.13855](https://doi.org/10.1001/jama.2024.13855)

## Topics

p-tau217 · p-tau217 · amyloid probability score 2 (APS2) · Aβ42/40 ratio · mass spectrometry-based plasma assay · cerebrospinal fluid Aβ42:Aβ40 ratio · blood-based Alzheimer disease biomarker test · primary care cohort · secondary care cohort · Biomarker cutpoints · prospective biweekly plasma analysis · positive predictive value · negative predictive value · diagnostic accuracy of primary care physicians · diagnostic accuracy of dementia specialists · subjective cognitive decline · mild cognitive impairment · clinical Alzheimer disease diagnosis · Area under the curve (AUC) · computed tomographic scan in dementia workup

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```