# APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease

*PRI Rank #4 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 247 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-02931-w |
| Corresponding authors | Juan Fortea, Víctor Montal |
| Institution | Hospital de la Santa Creu i Sant Pau, Spain |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1038/s41591-024-02931-w](https://doi.org/10.1038/s41591-024-02931-w)

## Topics

APOE4 · Alzheimer's disease · APOE4 · Genetic risk factors · Genetic subtype · Apolipoprotein E · APOE genotype · Late-onset Alzheimer's disease · Amyloid deposition · neurodegeneration · APOE4 · Genetic subtype

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```