# Biomarker-based staging of Alzheimer disease: rationale and clinical applications

*PRI Rank #19 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 96 |
| Journal | Nature Reviews Neurology |
| Year | 2024 |
| DOI | 10.1038/s41582-024-00942-2 |
| Corresponding authors | Joseph Therriault |
| Institution | Douglas Research Institute, Canada |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1038/s41582-024-00942-2](https://doi.org/10.1038/s41582-024-00942-2)

## Topics

Biomarker-based staging · Alzheimer's disease · Amyloid PET · Tau PET · Cerebrospinal fluid biomarkers · Blood-based biomarkers · Aβ42/40 ratio · Phosphorylated tau · Preclinical Alzheimer's disease · ATN classification framework · Disease staging · Clinical diagnostic criteria · Neurodegeneration biomarkers · Cognitive impairment continuum · Biomarker cutpoints · Disease progression · clinical trial eligibility criteria · Disease-modifying therapies · Early detection · Blood-based diagnostics

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```