# Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial

*PRI Rank #18 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 97 |
| Journal | Alzheimer s Research & Therapy |
| Year | 2024 |
| DOI | 10.1186/s13195-024-01482-z |
| Corresponding authors | Dean Ornish |
| Institution | Preventive Medicine Research Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1186/s13195-024-01482-z](https://doi.org/10.1186/s13195-024-01482-z)

## Topics

mild cognitive impairment · Mild dementia · Alzheimer's disease · Multidomain lifestyle intervention · Montreal Cognitive Assessment (MoCA) · Clinical Global Impression of Change (CGIC) · Alzheimer's Disease Assessment Scale (ADAS-Cog) · Clinical Dementia Rating-Sum of Boxes · Aβ42/40 ratio · gut microbiome · Cognitive function · lifestyle-cognition correlation · Phase 2 randomized controlled trial · wait-list control group · plasma amyloid biomarker · cognitive improvement · Disease progression · Conversion to AD dementia · Multidomain lifestyle intervention · biomarker-lifestyle correlation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```