# Multifaceted roles of APOE in Alzheimer disease

*PRI Rank #16 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 110 |
| Journal | Nature Reviews Neurology |
| Year | 2024 |
| DOI | 10.1038/s41582-024-00988-2 |
| Corresponding authors | Bradley T. Hyman, Alberto Serrano‐Pozo |
| Institution | Massachusetts General Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1038/s41582-024-00988-2](https://doi.org/10.1038/s41582-024-00988-2)

## Topics

Apolipoprotein E · Alzheimer's disease · APOE4 · APOE2 · APOE3 · Amyloid-beta · Tau accumulation · neurodegeneration · lipid metabolism · blood-brain barrier · Neuroinflammation · synaptic function · Apolipoprotein E isoforms · cerebrovascular function · Microglial activation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```