# Associations of semaglutide with first‐time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real‐world data in the US

*PRI Rank #12 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 129 |
| Journal | Alzheimer s & Dementia |
| Year | 2024 |
| DOI | 10.1002/alz.14313 |
| Corresponding authors | Rong Xu |
| Institution | Case Western Reserve University, United States |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1002/alz.14313](https://doi.org/10.1002/alz.14313)

## Topics

semaglutide · GLP-1 receptor agonist · type 2 diabetes mellitus · Alzheimer's disease · target trial emulation · electronic health records · nationwide real-world data · neurodegeneration · Neuroinflammation · Cox proportional hazards model · Kaplan-Meier survival analysis · insulin comparator · antidiabetic medications comparison · first-time AD diagnosis · obesity status subgroup analysis · AD-related medication prescriptions · hazard ratio · TriNetX database · GLP-1RA class comparison · neuroprotection

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```