# Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies

*PRI Rank #10 · Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 149 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.abm6131 |
| Corresponding authors | Paras S. Minhas, Jeffrey R. Jones, Amira Latif‐Hernandez, Katrin I. Andreasson |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026)

**Paper link:** [10.1126/science.abm6131](https://doi.org/10.1126/science.abm6131)

## Topics

indoleamine-2,3-dioxygenase 1 (IDO1) · kynurenine (KYN) · tryptophan metabolism · astrocyte metabolism · hippocampal glucose metabolism · aryl hydrocarbon receptor · monocarboxylate transporter · Amyloid β oligomers · Tau oligomers · glycolysis suppression · hippocampal long-term potentiation · lactate shuttle · astrocyte-neuron metabolic coupling · IDO1 inhibition · Alzheimer's disease mouse models · Cerebral glucose metabolism · AD proteomic studies · IDO1 inhibitor repurposing · astrocytic lactate production · neuronal lactate uptake

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```