# Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance

*PRI Rank #6 · Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 17 |
| Journal | International Journal of Biological Macromolecules |
| Year | 2024 |
| DOI | 10.1016/j.ijbiomac.2024.135844 |
| Corresponding authors | Suhong Chen, Guiyuan Lv, Jie Su |
| Institution | Zhejiang Chinese Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026)

**Paper link:** [10.1016/j.ijbiomac.2024.135844](https://doi.org/10.1016/j.ijbiomac.2024.135844)

## Topics

Cordyceps polysaccharide · polycystic ovary syndrome · insulin resistance · Gut microbiota · LPS/TLR4 pathway · TLR4/MyD88/NF-κB inflammatory pathway · Hirsutella sinensis · gut-derived LPS · intestinal barrier · hyperandrogenemia · glucose-lipid metabolism · Gram-negative bacteria · norank_f__Desulfovibrionaceae · Helicobacter · insulin signaling · ovarian polycystic lesions · estrous cycle · triple helix structure polysaccharide · systemic inflammation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```