# Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway

*PRI Rank #20 · Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 12 |
| Journal | Frontiers in Pharmacology |
| Year | 2024 |
| DOI | 10.3389/fphar.2024.1370619 |
| Corresponding authors | Guolin Chai, Fangdi Hu |
| Institution | Lanzhou University, China |

**Ranking page:** [Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026)

**Paper link:** [10.3389/fphar.2024.1370619](https://doi.org/10.3389/fphar.2024.1370619)

## Topics

Hemerocallis citrina · total phenolics from H. citrina leaves (HLTP) · PI3K/AKT pathway · network pharmacology · corticosterone-induced PC12 cell damage model · quercetin · rutin · Apigenin · Isoquercitrin · AKT1 · molecular docking · 4-O-Caffeoylquinic acid · oxidative stress · mitochondrial dysfunction · Caspase-3 · Bcl-2/Bax ratio · reactive oxygen species (ROS) · mitochondrial membrane potential (MMP) · cytochrome C (Cyt-C) · neuronal cell protection

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Agriculture and Biological Studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/agriculture-and-biological-studies/2026. Accessed 2026-10-29.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```