# Multi-pass, single-molecule nanopore reading of long protein strands

*PRI Rank #5 · Topics and Trends in Most Cited Advanced biosensing and bioanalysis techniques Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/advanced-biosensing-and-bioanalysis-techniques/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 111 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07935-7 |
| Corresponding authors | Jeff Nivala |
| Institution | University of Washington, United States |

**Ranking page:** [Topics and Trends in Most Cited Advanced biosensing and bioanalysis techniques Papers, Class of 2026](https://pri.pepkio.com/top-papers/advanced-biosensing-and-bioanalysis-techniques/2026)

**Paper link:** [10.1038/s41586-024-07935-7](https://doi.org/10.1038/s41586-024-07935-7)

## Topics

Nanopore sequencing · Single-molecule protein sequencing · ClpX unfoldase · CsgG nanopore · protein translocation · two-residue stepping mechanism · Single-molecule protein sequencing · post-translational modification mapping · phosphorylation detection · multi-pass protein rereading · Single-molecule protein sequencing · biophysical signal modeling · residue volume and charge · full-length proteoform analysis · protein domain unfolding · single-amino-acid substitution sequencing · electrophoretic protein threading · unfoldase motor mechanism

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Advanced biosensing and bioanalysis techniques Papers, Class of 2026. https://pri.pepkio.com/top-papers/advanced-biosensing-and-bioanalysis-techniques/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```